Saskatchewan has become the third province to unschedule naloxone, which means the drug which reverses the effects of opioids will be more readily available.
Naloxone had only been available through a pharmacist.
"This change allows our community-based organizations to play a key role in getting [take home naloxone] kits into the hands of individuals at risk," said Health Minister Jim Reiter.
The move comes as an administrative bylaw by the Saskatchewan College of Pharmacy Professionals.
"We feel this will further improve access for the people of Saskatchewan to obtain lifesaving Take Home Naloxone kits and help prevent further deaths due to overdoses," said SCPP Registrar Jeana Wendel.
British Columbia and Alberta have already made similar changes.